A mutation threshold distinguishes the anti - tumorigenic effects of the mitochondrial gene
نویسندگان
چکیده
Dipartimento di Scienze Ginecologiche, Ostetriche e Pediatriche, Genetica Medica, Università di Bologna, Bologna 40138, Italy Dipartimento di Biologia Evoluzionistica Sperimentale,Università di Bologna, Bologna 40126, Italy Unità Operativa di Anatomia e Istologia Patologica, Policlinico Universitario S. Orsola-Malpighi, Bologna, Bologna 40138, Italy Laboratorio di Oncologia Sperimentale, Istituti Ortopedici Rizzoli, Bologna 40136, Italy Sezione di Cancerologia, Dipartimento di Patologia Sperimentale, Università di Bologna 40126, Dipartimento di Patologia Sperimentale, Università di Bologna, Bologna 40126, Italy Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna 40123, Italy Dipartimento di Ematologia e Scienze Oncologiche, Università di Bologna, Bologna 40138, Italy
منابع مشابه
P167: Effect of Mitochondrial Mutation on Depression and Anxiety
Mitochondria are membrane-enclosed organelle found in most eukaryotic cells, which known as power house in cells. This organelle transforms energy into forms that are usable by the cell. The most common psychiatric disorders such as depression and anxiety can be linked to mitochondrial disorders. Furthermore, mutations of mitochondrial or nuclear DNA (mtDNA and nDNA, respectively) have been lin...
متن کاملP-213: Mutation Analysis of Mitochondrial ND4L Gene in Iranian Infertile Men with Varicocele
Background: Varicocele is the abnormal tortuosity and dilatation of the veins of the pampiniform plexus within the spermatic cord. Varicocele-related pathology is suspected in infertility as it leads to elevated temperatures in the scrotum and testes, which has a deleterious effect on spermatogenesis. In Varicocele patients, ROS production is enhanced and total antioxidant capacity (TAC) is red...
متن کاملNovel Missense Mitochondrial ND4L Gene Mutations in Friedreich's Ataxia
Objective(s) The mitochondrial defects in Friedreich's ataxia have been reported in many researches. Mitochondrial DNA is one of the candidates for defects in mitochondrion, and complex I is the first and one of the largest catalytic complexes of oxidative phosphorylation (OXPHOS) system. Materials and Methods We searched the mitochondrial ND4L gene for mutations by TTGE and sequencing on 30...
متن کاملMitochondrial gene mutation screening in hearing loss patients, Hormozgan, Iran
Introduction: Hearing loss is the most frequent sensory disorder occurs in 1/1000 newborns. About 50% of hearing loss cases are due to genetic causes. Mutation in MTRNR1(A1555G), MTTL1(A3243G) and MTTS1(A7445G) are known to be one of the important cause of nonsyndromic Sensorineural hearing loos in some populations. This study aims to demonstrate the frequency of three mitochondrial mutatio...
متن کاملLack of Association of Mitochondrial A3243G tRNALeu Mutation in Iranian Patients with Type 2 Diabetes
Many kinds of mutations in mitochondrial (mt) DNA have been reported to be related to the development of Diabetes Mellitus (DM), this type of diabetes has also been shown to be influenced by other genetic factors and/or environmental factors. Among them, tRNALeu(UUR) and its adjacent mtDNA NADH dehydrogenase subunit 1(ND1) region within the mt genome are linked to high susceptibility to DM. A p...
متن کامل